Prof. Giuseppe Legname

Full Professor


PhD program coordinator

Prion Biology Laboratory

Giuseppe Legname earned his Doctor of Philosophy at the University of Warwick, UK. After a long spell in industry in the field of immunotherapy, he moved to the National Institute for Medical Research (NIMR), Medical Research Council in London, UK as a Research Associate. In 1999 he became Assistant Adjunct Professor, and later Associate Adjunct Professor, at the Institute for Neurodegenerative Diseases (IND), University of California at San Francisco, USA, under the direction of 1997 Nobel Laureate Professor Stanley B. Prusiner. Since then he has been involved in basic research projects in the field of Prion Biology and Disease. In 2006 he joined the faculty of SISSA in Trieste as Associate Professor at the Department of Neuroscience. Currently he is the Coordinator of the PhD Program in Functional and Structural Genomics at SISSA and member-elect of the Academic Senate. He is a reviewer for several International journals, academic editor for PLoS ONE and co-author of various patents. The main focus of his research program is the physiological function of the prion protein in mammals and the mechanisms of prion replication as well as the structural characterization of molecular determinants for prion infectivity.

Last author:

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.

Abskharon RN, Giachin G, Wohlkonig A, Soror SH, Pardon E, Legname G, Steyaert J.

J Am Chem Soc. 2014 Jan 22;136(3):937-44. doi: 10.1021/ja407527p. Epub 2014 Jan 8.

co-correspoding authors

Early structural features in mammalian prion conformation conversion.

Legname G.

Prion. 2012 Jan-Mar;6(1):37-9. doi: 10.4161/pri.6.1.18425. Review.

Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells.

Didonna A, Legname G.

Mol Neurodegener. 2010 Aug 9;5:29. doi: 10.1186/1750-1326-5-29.


First author:

Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.

Legname G, Nguyen HO, Peretz D, Cohen FE, DeArmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19105-10. Epub 2006 Dec 1.

Strain-specified characteristics of mouse synthetic prions.

Legname G, Nguyen HO, Baskakov IV, Cohen FE, Dearmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2168-73. Epub 2005 Jan 25. Erratum in: Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14642.

Synthetic mammalian prions.

Legname G, Baskakov IV, Nguyen HO, Riesner D, Cohen FE, DeArmond SJ, Prusiner SB.

Science. 2004 Jul 30;305(5684):673-6.