Group Leader
ICGEB
The main focus of the laboratory is the molecular and cell biology of virus-host interactions. The Group has a long-standing interest in HIV-1 transcriptional and post-transcriptional nuclear regulation and has recently become interested also in Flaviviruses such as tick-borne encephalitis virus (TBEV) and hepatitits C virus (HCV). To this end, the lab has developed a platform of tools for the study of the virus-host crosstalk: from single protein-protein interactions to the 3D dynamics of host and viral components. We are also interested in implementing viral diagnostics for developing countries by technically supporting local scientists and by developing point-of-care portable devices in collaboration with industrial partners.
Some recent papers:
Albornoz A, Carletti T, Corazza G, Marcello A. The stress granule component TIA-1 binds Tick-borne Encephalitis Virus RNA and is Recruited to Perinuclear Sites of Viral Replication to inhibit viral translation. J Virol 2014.
Anderson I, Low JS, Weston S, Weinberger M, Zhyvoloup A, Labokha AA, Corazza G, Kitson RA, Moody CJ, Marcello A, Fassati A. Heat shock protein 90 controls HIV-1 reactivation from latency. Proc Natl Acad Sci USA 2014.
Miorin, L, Romero-Brey, I, Maiuri, P, Hoppe, S, Krijnse-Locker, J, Bartenschlager, R, Marcello, A. Three Dimensional Architecture of Tick-borne Encephalitis Virus Replication Sites and Trafficking of the Replicated RNA. J Virol 2013 Jun; 87 (11): 6469-81.
Marcello, A, Sblattero, D, Cioarec, C, Maiuri, P, Melpignano, P. A deep-blue OLED-based biochip for protein microarray fluorescence detection. Biosensors and Bioelectronics. 2013 46C: 44-47.
Roesch F, Meziane O, Kula A, Nisole S, Porrot F, Anderson I, Mammano F, Fassati A, Marcello A, Benkirane M, Schwartz O. Hyperthermia Stimulates HIV-1 Replication. PLOS Pathogens. 2012, 8(7) e1002792.
Maiuri P, Knezevich A, De Marco A, Mazza D, Kula A, McNally J, Marcello A. Fast transcription rates of RNA Polymerase II in human cells. EMBO Reports. 2011 Dec 1; 12 (12): 1280-5.