Prof. Maria Laura Bolognesi

Associate Professor

University of Bologna

Department of Pharmacy and Biotechnology

Maria Laura Bolognesi earned a Ph.D. in Pharmaceutical Sciences in 1996 from the University of Bologna, under the guidance of Professor Carlo Melchiorre. After postdoctoral studies at the University of Minnesota with Professor Philip S. Portoghese, in 1998 she began her academic career at the University of Bologna where she is currently an Associate Professor of Medicinal Chemistry. In 2009 she was awarded a position of Distinguished Visiting Professor at Universidad Complutense de Madrid, and in 2014 a position of Special Visiting Researcher (Pesquisador Visitante Especial) at University of Brasilia. Her current research interests span the design and synthesis of small molecules as probes for the investigation of biological processes or as drug candidates.

Selected publications: 

Nepovimova E, Uliassi E, Korabecny J, Peña-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML. Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects. J Med Chem. 2014 doi: 10.1021/jm5010804

Bolognesi ML. Polypharmacology in a single drug: multitarget drugs. Curr Med Chem. 2013; 20(13):1639-45.

Staderini M, Aulić S, Bartolini M, Tran HN, González-Ruiz V, Pérez DI, Cabezas N, Martínez A, Martín MA, Andrisano V, Legname G, Menéndez JC, Bolognesi ML. A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases. ACS Med Chem Lett. 2012 ; 4(2):225-9. doi: 10.1021/ml3003605.

Pieretti S, Haanstra JR, Mazet M, Perozzo R, Bergamini C, Prati F, Fato R, Lenaz G, Capranico G, Brun R, Bakker BM, Michels PA, Scapozza L, Bolognesi ML, Cavalli A. Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism. PLoS Negl Trop Dis. 2013; 7(1):e2012. doi: 10.1371/journal.pntd.0002012.

Lizzi F, Veronesi G, Belluti F, Bergamini C, López-Sánchez A, Kaiser M, Brun R, Krauth-Siegel RL, Hall DG, Rivas L, Bolognesi ML. Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile. J Med Chem. 2012; 55(23):10490-500. doi: 10.1021/jm301112z.