Group Leader
ICGEB
Oscar R. Burrone is head of the Molecular Immunology Laboratory at ICGEB Trieste. A the moment the group is focused in: i) the development of DNA-based vaccines for Dengue virus, ii) the use of genetic strategies for passive delivery of recombinant antibodies, iii) the molecular biology of rotavirus replication and iv) the mechanisms of quality control of proteins within the secretory pathway.
Some recent publications:
Rotavirus Viroplasm Proteins Interact with the Cellular SUMOylation System: Implications for Viroplasm-Like Structures Formation. Campagna M., Marcos-Villar L., Arnoldo F., de la Cruz-Herrera C.F., Gallego P., González-Santamaría J., González D., Lopitz-Otsoa F., Rodríguez M.S., Burrone, O.R., Rivas, C. (2013) J. Virol., 87:807-817
Selective Targeting of Proteins within the Secretory Pathway for Endoplasmic Reticulum-Associated Degradation. Vecchi L., Petris G., Bestagno M., Burrone O.R. (2012) J. Biol. Chem. 287:20007-15
CD4 and BST-2/Tetherin retro-translocate from Endoplasmic Reticulum to cytosol as partially folded and multimeric molecules. G. Petris, A. Casini, L. Sasset, F. Cesaratto, M. Bestagno, A. Cereseto, O.R. Burrone. (2014) J.Biol.Chem. 2891:1-12
Rotavirus Increases Levels of Lipidated LC3 Supporting Accumulation of Infectious Progeny Virus without Inducing Autophagosome Formation. Arnoldi F., De Lorenzo G., Mano M., Schraner E.M., Wild P., Eichwald C., Burrone O.R. (2014) Plos ONE, 9 (4): e95197